Cyclic Mechanical Stress and Trabecular Meshwork Cell Contractility
نویسندگان
چکیده
منابع مشابه
Cyclic mechanical stress and trabecular meshwork cell contractility.
PURPOSE Ocular pulse decreases outflow facility of perfused anterior segments. However, the mechanism by which conventional outflow tissues respond to cyclic intraocular pressure oscillations is unknown. The purpose of the present study was to examine responses of trabecular meshwork (TM) cells to cyclic biomechanical stress in the presence and absence of compounds known to affect cell contract...
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PURPOSE To investigate the changes in gene expression induced by cyclic mechanical stress (CMS) in trabecular meshwork (TM) cells. METHODS Human TM cultures from three donors were plated on type I collagen-coated flexible silicone bottom plates and subjected to 15% stretching, one cycle per second for 6 h. Non-stressed parallel control cultures were incubated under the same conditions in the ...
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&gl~$g. Anterior segment perfusion povides a tool for determining flow in the trabecular outflow pathway only, contrary to perfusion of whole eyes in which 10-3046 of the outflow comes on account of the uveoscleral pathway. Since disposed human eyes are not abundantly available, especially not as a pair, it would be convenient to develop a model in which one half of an anterior segment could se...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2009
ISSN: 1552-5783
DOI: 10.1167/iovs.08-2694